Application of Ultrafiltration Technology in the Preparation of Compound Danshen

Ultrafiltration technology is widely used in the production of Compound Danshen Injection and Oral Liquid.

Ultrafiltration in the preparation of Compound Danshen Injection can remove bacteria, pyrogens, and impurities, improve clarity, retain effective components, enhance efficacy, and is safe and non-toxic.

Advantages:

Excellent sterilization effect: Ultrafiltration yields a sterile and clear solution, replacing heat sterilization and avoiding precipitation caused by heat. It can also remove some pigments.

Excellent pyrogen removal effect: Pyrogen removal meets pharmacopoeia requirements.

Excellent impurity removal effect: Improves the clarity of injections and oral liquids. Tannins, starch, resins, and proteins in traditional Chinese medicine extracts are difficult to remove completely using traditional water-alcohol methods. Using an ultrafiltration membrane with a specific rejection value can remove these impurities, achieving improved clarity. Clarity remains unchanged during long-term storage.

Flowchart:

Supply → Plate and Frame Filtration → Ultrafiltration → Injection or Oral Liquid